| Aaron Neville |    | Peter uses the Aaron Neville megaphone which enables him to speak like Aaron Neville |
| About Schmidt | | Stewie's bath with Kathy Bates is a reference to a scene in About Schmidt. |
| Boy in the Plastic Bubble | | Mention of the movie "Boy in the Plastic Bubble", starring John Travolta. |
| Bryant Gumbel | | This host of HBO's "Real Sports" is mentioned for a second time in the show's run. |
| Cobra Kai | | The name of the bad guys in The Karate Kid |
| Desperate Housewives | | Stewie tells the audience to go watch Desperate Housewives on ABC for five seconds to see how ugly the women are. Desperate Housewives' timeslot competes with both Family Guy and American Dad! on FOX and, in most of Canada, Global. |
| Face/Off | | When the doctor tells Lois and Peter that Stewie will need to be in a plastic bubble, Peter asks if he'll have to take his face off, like in "Face/Off", in which the protagonist and antagonist traded faces. |
| Fire Island | | Fire island is famous as a gay vacation spot. |
| Gavin McLeod | | Gavin McLeod (Love Boat Captain) shows up to ask if people want to join his church. |
| Happy Days | | The end credits are from Happy Days |
| Hitting the Jukebox | | Fonz hits Mr. Cunningham in the crotch, fixing his erectile dysfunction. This parodizes the way Fonz would hit the jukebox at Arthur's to make it play a record. |
| Holy Water | | Frances sprinkles contaminated holy water on Stewie |
| Immigrants | | A stereotype is played out here, with Mexican immigrants being viewed as party animals who want to fight. |
| Jaws | | When the shark is looking up at the two pairs of legs and is talking about eating them. |
| Jehova Witnesses | | Peter, while trying to discover his religion tries spreading the 'word of God.' |
| Kirk Cameron | | Kirk Cameron (who did not provide his voice in this episode) appears at the First United Church of The Fonz to convert some of the members of Peter's church to Christianity. In reality, the former Growing Pains star is an evangelical Christian himself. |
| Kobe Bryant | | Peter makes reference to the recent arrest of Kobe Bryant for raping a girl. |
| Madonna | | Peter, Brian, and Francis mock Madonna for the bad choices she made of dating celebrities such as Dennis Rodman. |
| Network Announcers | | Family Guy parodizes the fact that television networks always place a serious drama after a comedic sitcom. |
| Office Space | | Bill Lumbergh from "Office Space" makes an appearance. |
| Paula Abdul | | Peter dances with Paula Abdul in footage of the video for "Opposites Attract". He is superimposed over the animated role of MC Skat Kat, and sings an altered version of the original song's lyrics. |
| Quantum Leap | | The description and clip of Jesus during Peter's explaination is a parody of Sam Becket in Quantum Leap including the infamous 'Oh Boy' and Don P. Bell... |
| Rock Around the Clock | | The ending song of the episode is "Rock Around the Clock" by Bill Haley. |
| Sesame Street | | When Stewie's in the bubble they flashback to the classic pinball counting skit from Sesame Street |
| Space Ghost | | When Francis baptises Stewie "in the name of the father, the son, and the Holy Ghost", Peter adds in "and Space Ghost". "Space Ghost" was the protagonist of both an old Hannah-Barbera television show, and a parody sitcom from the mid 90s. |
| Star Wars | | Peter says "May the Fonz be with you". This is a parody on the Sar Wars line "May the Force be with you". |
| The Fonz | | The title of this episode references the Fonz from the sitcom "Happy Days." |
| The Jeffersons | | Sherman Hemsley shows up to ask people to convert to the church of George Jefferson. |
| The View | | Brian torments Stewie by forcing him to watch The View. |
| Vatican City | | The holy city of the Roman Catholic faith is featured in this episode. |
| Vaudeville | | The two characters who do the vaudeville acts are back. |
