| Alien / Tremors |    | An alien busts out of the chest of a medical patient. The alien appears much like the worm creatures from Tremors. |
| Bill Clinton | | Chris throws an egg at a naked prancing Bill Clinton |
| David Schwimmer | | Lois implies that David Schwimmer, the actor who played Ross in the 90s sitcom Friends, is gay |
| Dig'em | | |
| Dog Day Afternoon | | The end scene with Brian bares a resemblance to Dog Day Afternoon with Al Pacino |
| Empire Strikes Back | | |
| Gay marriage | | Jasper is getting married to his male partner, however, Mayor West tries to get gay marriage banned from Quahog. The concept of gay marriage is a very controversial topic with many right-wing groups claiming that marriage should be between a man and a woman. |
| Homeland Security | | This government organization is satirized by Stewie after being able to sneak into the runway control room. |
| John Q | | Brian takes Mayor Adam West hostage, much like Denzel Washington's character does to a hospital in this film. |
| Matthew McConaughey | | |
| McGruff the Crime Dog | | Stewie calls Jasper "McButt", which is a pun on the name of the animated dog mascot for the "Take a Bite Out of Crime" advertisements. |
| Moby Dick | | Peter remembers the time Moby Dick came to stay |
| Mushrooms | | Chris and his friends take this hallucinogenic drug. The effect, however, is making all three of them sound like Barry White. |
| Popeye | | Classic cartoon character Popeye is shown being diagnosed at the hospital by Dr Hartman |
| Ron Howard | | Stewie makes several suggestive remarks that he is going to kill the "Apollo 13" director and star of "American Graffiti". |
| SARS | | This Asian-oriented disease also serves as the acronym for the Society of Arch-Republican Students, the young republicans group Chris joins. |
| Sex in the City | | Brian has to watch Sex and the City with a couple of gay men in order to get them to sign his petition for gay marriage |
| Sound of Music | | Jasper is seen sat watching the musical the Sound of Music, a stereotypical image of gay men is that they all like watching musicals |
| Space Shuttle Challenger Disaster | | Brian says that he was with a woman three years before this event. |
| Stratego | | Mayor Adam West coughs up this famous Hasbro board game. |
| Techno | | |
| The Proclaimers | | Peter sings "I'm Gonna Be'' with the Scottish folk band The Proclaimers |
| The YMCA | | A nonprofit health organization that became notorious for housing gay men due to the song by the same name, performed by the Village People. |
| Volkswagen Scirocco | | Stewie finds a key to this car in the candy dish at the Pewterschmidt's house. This car was produced by Volkswagen from 1974 to 1992. A new Scirocco is planned for 2008. |
| Wag the Dog | | Mayor Adam West looks through a list of items to use as a distraction for a political scandal. This was also the plot for this film, which starred Robert DeNiro and Dustin Hoffman. |
| Witch Doctor | | When Brian asks Quagmire to sign his petition, he does his famous "Giggity" followed by the chorus to this hit song. |
| Young Republicans | | Chris joins the Young Republicans |
